ConserV Bioscience is pleased to announce the publication of our most recent work to continue to decipher the mechanism of action of FLU-v, our broad-spectrum influenza vaccine.
Previously, we have demonstrated that FLU-v vaccination triggered cross-reactive T-cell responses and antigen-specific antibodies. These antibodies are not neutralising as they target internal proteins of the influenza virus.
We were intrigued to find whether FLU-v antibodies could play a role in fighting influenza infection through mechanisms such as antigen-dependent cell cytotoxicity (ADCC), induced mainly by IgG1 and IgG3 antibody isotypes. This manuscript shows that FLU-v induces both IgG1 and IgG3 antibodies measured in serum samples collected from vaccinated volunteers that took part in a phase IIb clinical study within the UNISEC Consortium funded by Horizon 2020.
Isotyping of the antibodies was carried out at the Norwegian Institute of Public Health (NIPH) and functional assays conducted at the James Cook University (Australia) demonstrated that FLU-v specific antibodies were able to activate natural killer cells, an immune cell type associated with killing virus-infected cells.
We would like to thank our collaborators at the NIPH and at James Cook University in Melbourne for their excellent contributions to this paper.
The paper can be read here: https://www.mdpi.com/2076-393X/13/11/1084/pdf (Open access)